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KMID : 0644120130260040048
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Journal of Oriental Gynecology
2013 Volume.26 No. 4 p.48 ~ p.65
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Effects of Herbal Medicine on Breastfeeding - Analysis of Marker Substances in Saenghwa-tang by HPLC and LC/MS/MS -
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Park Ka-Young
Lee Ah-Young
Ban Ji-Hye
Park Jung-Kyung
Lee Eun-Hee
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Abstract
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Objectives: We took breast milk samples and analyzed them using HPLC and LC/MS/MS, to evaluate the effects of taking Saenghwa-tang during breastfeeding on breast milk.
Methods: The study participants were 20 lactating women who admitted in Korean medical postpartum care center. Breast milks were collected from paticipants who have been administrated Saenghwa-tang for more than 3 days. We used HPLC and LC/MS/MS for the determinations of amygdalin, liquiritins, 6-gingerol, decursin and decursinol angelate in Saenghwa-tang.
Results:
1. Participants' Mean±S.D (standard deviation) of age is 31.05±1.96, and 15 participants had normal delivery and 5 participants had cesarean delivery. 12 participants were primipara and 8 participants were multipara. Mean±S.D of lactating date is 9.4±0.94.
2. Using HPLC, we learned LOQ level peak that matches the peak retention time of standard components of Saenghwa-tang was not detected from 20 breast milk samples.
3. Using LC/MS/MS, decursin of Angelicae Gigantis Radix was detected from HMSP 02, HMSP 04, HMSP 06, HMSP 11, and the each concentrations are 16, 2, 64, 11 ppb. Liquiritin of Glycyrrhizae Radix was not detected from HMSP 13~HMSP 18.
Conclusions: Data obtained by this approach shows that this method is reliable and suitable for determining the safety of taking Saenghwa-tang during breastfeeding.
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KEYWORD
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Saenghwa-tang, Breastfeeding, HPLC, LC/MS/MS, Herbal medicine, Marker Substance
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